Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 920284생성일: 2026년 10월 26일
Aluminium lithium hydride → 5-(Hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile
https://huagongshe.com/reaction/920284
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 3-Cyano-4-(5-trifluoromethyl-pyridin-2-yloxy)-benzoic acid methyl ester | HCID 66825341 | — |
| 촉매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-(Hydroxymethyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzonitrile | HCID 66825657 | 60.7% |
반응 단계
To a solution of 3-cyano-4-(5-trifluoromethyl-pyridin-2-yloxy)-benzoic acid methyl ester (23 g, 0.070 mol) in anhydrous THF (200 mL), was added LiAlH4 (4.07 g, 0.11 mmol) portionwise at −78° C. The reaction mixture was warmed to −55° C. slowly and stirred for 20 mins, diluted with water (3 mL 0.16 mmol, slow addition), filtered and concentrated. Purification via FC (PE/EtOAc=10/1 to 5/1) afforded the title product as a colorless oil (12.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09273054B2 |
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| 출처 데이터셋 | uspto-grants-2016_03 |
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| ORD ID | ord-fde3559987d24f0fb0278193cb60faaf |
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| 출처 메모 | uspto-grants-2016_03 |
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