Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-Fluoro-4-(2-hydroxyethyl)phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Borane | HCID 6331 | — |
| 반응물 | 3-Fluoro-4-hydroxybenzeneacetic acid | HCID 68014 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-4-(2-hydroxyethyl)phenol | HCID 45119081 | 94.5% |
반응 단계
To a solution of 2-(3-fluoro-4-hydroxyphenyl)acetic acid (9.8 g, 57.6 mmol) in THF (500 mL) was added dropwise 57.6 mL of borane (10M in Me2S) at room temperature. The reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was added to CH3OH and was concentrated under reduced pressure. The residue was partitioned between EtOAc (800 mL) and water (100 mL). The organic layer was dried and concentrated to dryness to give the title product (8.5 g, 76%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09273054B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-96fe742a6f6944548b58cbf634560b95 |
| 출처 메모 | uspto-grants-2016_03 |