3-(2-Hydroxyethyl)benzonitrile → 3-[2-(1-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidin-8-yloxy)-ethyl]-benzonitrile

반응식

[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8].Cl[C:13]1[CH:23]=[C:17]2[N:18]([CH3:22])[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:24])[N:14]=1>>[CH3:22][N:18]1[CH2:19][CH2:20][CH2:21][N:16]2[C:15](=[O:24])[N:14]=[C:13]([O:1][CH2:2][CH2:3][C:4]3[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=3)[C:7]#[N:8])[CH:23]=[C:17]12

참가 물질

반응물 2

HCID 149267273-(2-Hydroxyethyl)benzonitrile

HCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

생성물 1

HCID 712367313-[2-(1-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidin-8-yloxy)-ethyl]-benzonitrile

실험 절차

The title compound or its salt was prepared by a procedure similar to that described for E11 starting from of 3-(2-hydroxyethyl)benzonitrile and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

출처 및 근거

ORD 기록: ord-c1aa4f1b9fc04bf18c88673e4e461bed
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09273054B2

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