3-Fluoro-4-(trifluoromethyl)benzyl alcohol → 8-((3-fluoro-4-(trifluoromethyl)benzyl)oxy)-1-isopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:12][OH:13])[CH:5]=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].Cl[C:15]1[CH:27]=[C:19]2[N:20]([CH:24]([CH3:26])[CH3:25])[CH2:21][CH2:22][CH2:23][N:18]2[C:17](=[O:28])[N:16]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[C:8]([F:10])([F:11])[F:9])[CH2:12][O:13][C:15]1[CH:27]=[C:19]2[N:20]([CH:24]([CH3:25])[CH3:26])[CH2:21][CH2:22][CH2:23][N:18]2[C:17](=[O:28])[N:16]=1참가 물질
3
실험 절차
The title compound or its salt was prepared by a procedure similar to that described for E2 starting from (3-fluoro-4-(trifluoromethyl)phenyl)methanol and 8-chloro-1-isopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.
출처 및 근거
- ORD 기록
- ord-f9265ca2ec2648e894ad57b2cd66ef96
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09273054B2
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