2,3-Difluorobenzylamine → 8-(2,3-Difluoro-benzylamino)-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

반응식

[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][NH2:10].Cl[C:12]1[CH:22]=[C:16]2[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]2[C:14](=[O:23])[N:13]=1>>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][NH:10][C:12]1[CH:22]=[C:16]2[N:17]([CH3:21])[CH2:18][CH2:19][CH2:20][N:15]2[C:14](=[O:23])[N:13]=1

참가 물질

반응물 2

HCID 27369412,3-Difluorobenzylamine

HCID 717434718-Chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-A]pyrimidin-6(2H)-one

생성물 1

HCID 712365548-(2,3-Difluoro-benzylamino)-1-methyl-1,2,3,4-tetrahydro-pyrimido[1,6-a]pyrimidin-6-one

실험 절차

The title compound or its salt was prepared by a procedure similar to that described for E59 starting from (2,3-difluorophenyl)methanamine and 8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one.

출처 및 근거

ORD 기록: ord-ad3c4e8de46845c2a1b47d50cc3cb0a2
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09273054B2

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