Benzyl 3,3-difluorocyclobutane-1-carboxylate → 3,3-Difluorocyclobutane-1-carboxylic acid
반응식
[F:1][C:2]1([F:16])[CH2:5][CH:4]([C:6]([O:8]CC2C=CC=CC=2)=[O:7])[CH2:3]1>C(O)C.[Pd]>[F:1][C:2]1([F:16])[CH2:5][CH:4]([C:6]([OH:8])=[O:7])[CH2:3]1참가 물질
4
실험 절차
To a solution of benzyl 3,3-difluorocyclobutanecarboxylate (1.4 g, 6.2 mmol) in ethanol (50 mL) was added palladium on activated carbon (500 mg) and the reaction mixture was stirred at RT under an atmosphere of hydrogen (1 atm) for 12 h. The reaction mixture was filtered through a pad of CELITE® and the filtrate was concentrated to afford Intermediate 291A as pale yellow liquid (550 mg, 65% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.97-12.76 (m, 1H), 3.04-2.91 (m, 1H), 2.89-2.64 (m, 4H).
후처리
- filtrationThe reaction mixture was filtered through a pad of CELITE®
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-a3d70355b97948f4a5658a443bdef9b6
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09273058B2
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