2-(trifluoromethyl)imidazo[1,2-a]pyrazine → 2-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine

HRID 920969

반응식

HRID 920969 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[N:4]=[C:5]2[CH:10]=[N:9][CH:8]=[CH:7][N:6]2[CH:11]=1>CO.[Pd]>[F:12][C:2]([F:1])([F:13])[C:3]1[N:4]=[C:5]2[CH2:10][NH:9][CH2:8][CH2:7][N:6]2[CH:11]=1

참가 물질

4

반응물 1

HCID 32313062-(trifluoromethyl)imidazo[1,2-a]pyrazine

생성물 1

HCID 147199282-(trifluoromethyl)-5H,6H,7H,8H-imidazo[1,2-a]pyrazine수율 95.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

2-(Trifluoromethyl)imidazo[1,2-a]pyrazine 12b (2.40 g, 12.55 mmol) was dissolved in 100 mL of methanol, followed by addition of Pd—C (10%, 480 mg), and the reactor was purged with hydrogen for three times. After stirring for 12 hours, the reaction mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to obtain 2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 12c (2.30 g, yield 95.8%) as a yellow oil.

후처리

  1. customthe reactor was purged with hydrogen for three times
  2. filtrationthe reaction mixture was filtered
  3. washthe filter cake was washed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-08587bb78867441481980e766d248433
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273052B2

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