2-Hydrazinopyrazine → 2,2-difluoro-N'-pyrazin-2-yl-acetohydrazide difluoroacetate

반응식

[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:7][NH2:8].[F:9][CH:10]([F:19])[C:11]([O:13][C:14](=[O:18])[CH:15]([F:17])[F:16])=[O:12]>>[F:9][CH:10]([F:19])[C:11]([OH:13])=[O:12].[F:17][CH:15]([F:16])[C:14]([NH:8][NH:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:18]

참가 물질

반응물 2

HCID 14878232-Hydrazinopyrazine

HCID 2774048Difluoroacetic anhydride

생성물 1

HCID 866856482,2-difluoro-N'-pyrazin-2-yl-acetohydrazide difluoroacetate수율 78.2%

실험 절차

Pyrazin-2-yl-hydrazine 23a (1 g, 9 mmol) was added in an eggplant-shaped bottle (25 mL), followed by dropwise addition of difluoroacetic anhydride (4 g, 22.98 mmol) at 0° C. After stirring at room temperature for 3 hours, the reaction mixture was concentrated under reduced pressure to obtain crude 2,2-difluoro-N′-pyrazin-2-yl-acetohydrazide difluoroacetate 23b (2 g) as a brown oil. The product was used directly in the next reaction without purification.

후처리

concentrationthe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록: ord-08c3e720c3cb4b559ddc63c6d6bcdd93
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09273052B2

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