Potassium Carbonate → N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide

HRID 920994노트

반응식

HRID 920994 반응식
Cl.[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:21])([F:20])[F:19])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[CH:2]1([CH2:5][NH:6][C:7]([C:9]2[N:10]=[C:11]([C:18]([F:19])([F:20])[F:21])[N:12]3[CH2:17][CH2:16][NH:15][CH2:14][C:13]=23)=[O:8])[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 86685650N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro imidazo[1,5-a]pyrazine-1-carboxamide hydrochloride

생성물 1

HCID 68011901N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide수율 112.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide hydrochloride 24b (250 mg, 0.77 mmol) was dissolved in 10 mL of dichloromethane, followed by addition of potassium carbonate (320 mg, 2.30 mmol). After stirring for 4 hours, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain crude N-(cyclopropylmethyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxamide 24c (250 mg) as a yellow solid. The product was used directly in the next reaction without purification.

후처리

  1. filtrationthe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9cfd8df8bd854eabaaa57d9e669a35d5
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273052B2

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