4-Anilino-2,5-dichloropyrimidine → 5-chloro-N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-N4-phenylpyrimidine-2,4-diamine
반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]([Cl:15])=[CH:4][N:3]=1.[CH3:16][P:17]([C:20]1[N:25]=[C:24]([O:26][CH3:27])[C:23]([NH2:28])=[CH:22][CH:21]=1)([CH3:19])=[O:18]>>[Cl:15][C:5]1[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:7][C:2]([NH:28][C:23]2[C:24]([O:26][CH3:27])=[N:25][C:20]([P:17]([CH3:16])([CH3:19])=[O:18])=[CH:21][CH:22]=2)=[N:3][CH:4]=1참가 물질
3
실험 절차
This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-phenylpyrimidin-4-amine with 6-(Dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32)
후처리
- customThis compound can be prepared as in Example 32
출처 및 근거
- ORD 기록
- ord-76120a5edab24a31baea864262e52fcb