Triethylamine → HCID 68156975, 화합물

HRID 921375

반응식

HRID 921375 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([P:15]([CH3:18])([CH3:17])=[O:16])=[CH:11][CH:10]=2)[CH:3]=1.C(N(CC)CC)C.Cl.[NH2:27][N:28]1[CH2:35][CH:34]2[CH:30]([CH2:31][CH2:32][CH2:33]2)[CH2:29]1>C(O)C>[CH3:17][P:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:4]2[CH:3]=[C:2]([NH:27][N:28]3[CH2:35][CH:34]4[CH2:33][CH2:32][CH2:31][CH:30]4[CH2:29]3)[N:7]=[CH:6][N:5]=2)=[CH:10][CH:11]=1)([CH3:18])=[O:16]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 16213802Hexahydrocyclopenta(c)pyrrol-2(1H)-amine monohydrochlorideHCID 86668807HCID 86668807, 화합물

생성물 1

HCID 68156975HCID 68156975, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 6-chloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine (prepared as in Example 59: 0.12 mmol) in 2 mL of ethanol is added 50 L of triethylamine and 3-Amino-3-azabicyclo-[3,3,0]octane hydrochloride salt (19 mg, 0.12 mmol). The mixture is microwaved at 120 degrees until formation of the desired compound. The reaction mixture can then be filtered through a syringe filter and purified by prep-HPLC.

출처 및 근거

ORD 기록
ord-bd12bc48c8f34c27ab362c3bac4531c6
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273077B2

연결된 노트

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