Benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate → 1-(Azetidin-3-yl)-4-methylpiperazine

HRID 921642노트

반응식

HRID 921642 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:11][N:10](C(OCC3C=CC=CC=3)=O)[CH2:9]2)[CH2:4][CH2:3]1>CO.[Pd]>[NH:10]1[CH2:11][CH:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH2:9]1

참가 물질

4

반응물 1

HCID 86708494Benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate

생성물 1

HCID 206598001-(Azetidin-3-yl)-4-methylpiperazine수율 100.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of benzyl 3-(4-methylpiperazin-1-yl)azetidine-1-carboxylate (1.45 g, 5.01 mmol) and Pd/C (0.320 g, 0.150 mmol) in methanol (30 mL) was hydrogenated at 30 psi over the weekend. The reaction mixture was filtered through celite and the filtrate was concentrated. The crude product 1-(azetidin-3-yl)-4-methylpiperazine (0.78 g, 5.02 mmol, 100% yield) was obtained as colorless oil and used without purification.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a635ec9e7d954fdb96254ca6fa06cd72
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09273057B2

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