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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Potassium Carbonate → 2-(4-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-oxopiperazin-1-yl)-N-methylacetamide

HRID 921878
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HRID 921878 반응식
[Cl:1][C:2]1[C:7]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][C:9]2=[O:14])=[CH:6][C:5]([C:15]#[N:16])=[CH:4][C:3]=1[NH:17][C:18]1[N:23]=[C:22]([NH:24][CH:25]2[CH2:27][CH2:26]2)[C:21]2=[N:28][CH:29]=[C:30]([C:31]#[N:32])[N:20]2[N:19]=1.Br[CH2:34][C:35]([NH:37][CH3:38])=[O:36].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[C:3]([NH:17][C:18]2[N:23]=[C:22]([NH:24][CH:25]3[CH2:27][CH2:26]3)[C:21]3=[N:28][CH:29]=[C:30]([C:31]#[N:32])[N:20]3[N:19]=2)=[CH:4][C:5]([C:15]#[N:16])=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([CH2:34][C:35]([NH:37][CH3:38])=[O:36])[CH2:10][C:9]1=[O:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 154907452-Bromo-N-methylacetamideHCID 89922950HCID 89922950, 화합물

생성물 1

HCID 899228262-(4-(2-chloro-5-cyano-3-((7-cyano-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)-3-oxopiperazin-1-yl)-N-methylacetamide수율 25.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide
용매

실험 절차

To solution of 2-((2-chloro-5-cyano-3-(2-oxopiperazin-1-yl)phenyl)amino)-4-(cyclopropylamino)imidazo[2,1-f][1,2,4]triazine-7-carbonitrile (Example 628)(20 mg, 0.045 mmol) in DMF (0.5 mL) was added 2-bromo-N-methylacetamide (13.54 mg, 0.089 mmol) followed by K2CO3 (73.9 mg, 0.535 mmol) at room temperature and stirred at room temperature for 1 h, LC-MS indicated completion. Purification via preparative HPLC gave the title compound as a yellow solid (5.9 mg).

후처리

  1. customPurification via preparative HPLC

출처 및 근거

ORD 기록
ord-e6f208491eed46eaa0be1eb79ca0ec73
출처 데이터셋
uspto-grants-2016_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09273057B2

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