(6-Bromo-5-methoxypyridin-2-yl)methanol → 6-Bromo-5-methoxypicolinaldehyde

HRID 922374

반응식

HRID 922374 반응식
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][OH:9])[CH:5]=[CH:4][C:3]=1[O:10][CH3:11]>ClCCl.O=[Mn]=O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][C:3]=1[O:10][CH3:11]

참가 물질

4

반응물 1

HCID 16044667(6-Bromo-5-methoxypyridin-2-yl)methanol

생성물 1

HCID 222683396-Bromo-5-methoxypicolinaldehyde수율 63%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of (6-bromo-5-methoxypyridin-2-yl)methanol (2.30 g, 10 mmol) in dichloromethane (50 mL) was added MnO2 (8.0 g) at rt. The reaction mixture was stirred at rt for 24 h. After that time the reaction was cooled to rt, filtered to remove solids and concentrated under reduced pressure to give 6-bromo-5-methoxypicolinaldehyde (1.35 g, 63%) as an off-white solid: 1H NMR (400 MHz, CDCl3): δ 9.94 (s, 1H), 7.96 (d, J=8.4 Hz, 1H), 7.27 (d, J=8.0 Hz, 1H), 4.03 (s, 3H).

후처리

  1. temperatureAfter that time the reaction was cooled to rt
  2. filtrationfiltered
  3. customto remove solids
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a1ca2495e75946f0876c0ed96644e55b
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278940B2

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