Methanamine, N-methoxy-, hydrochloride (1:1) → 1-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one

HRID 922425노트

반응식

HRID 922425 반응식
[Br:1][C:2]1[C:3]([O:11][CH3:12])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[CH3:14]NOC.C[Mg]Br>>[Br:1][C:2]1[CH:10]=[C:6]([C:7](=[O:9])[CH3:14])[CH:5]=[N:4][C:3]=1[O:11][CH3:12]

참가 물질

4

반응물 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 457904665-Bromo-6-methoxy-3-pyridinecarboxylic acidHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 838940271-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one

실험 절차

5-Bromo-6-methoxynicotinic acid and N,O-dimethylhydroxylamine hydrochloride were treated in the similar manner to Reference Example 7(5), and then the resulting compound and methylmagnesium bromide were treated in the similar manner to Reference Example 7(6) to give 1-(5-bromo-6-methoxypyridin-3-yl)ethanone [Ex(296-1)] as a colorless powder.

출처 및 근거

ORD 기록
ord-df787c6a77c74c04923310bf2b837528
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278944B2

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