hydrogen chloride CPME → N-[4-(trans-2-aminocyclopropyl)-2-methylphenyl]benzamide hydrochloride

HRID 922548노트

반응식

HRID 922548 반응식
[C:1]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([C@@H:16]2[CH2:18][C@H:17]2[NH:19]C(=O)OC(C)(C)C)=[CH:12][C:11]=1[CH3:27])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28].COC1CCCC1>>[ClH:28].[NH2:19][C@@H:17]1[CH2:18][C@H:16]1[C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[C:11]([CH3:27])[CH:12]=1

참가 물질

3

반응물 2

HCID 66926893hydrogen chloride CPMEHCID 86729917tert-Butyl {trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropyl}carbamate

생성물 1

HCID 86729915N-[4-(trans-2-aminocyclopropyl)-2-methylphenyl]benzamide hydrochloride

실험 절차

tert-Butyl {trans-2-[4-(benzoylamino)-3-methylphenyl]cyclopropyl}carbamate (125.8 mg) was dissolved in 4N hydrochloric acid/cyclopentyl methyl ether solution (1.5 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (95.9 mg).

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-b95ec5a89708440e9cc9ff1fdf103d08
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278931B2

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