Potassium Hydroxide → HCID 86719692, 화합물

HRID 922664노트

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HRID 922664 반응식
[Cl:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[Cl:7].[OH-:8].[K+].[Br:10][CH2:11][C:12]1[CH:25]=[CH:24][C:23]2[C:22](=[O:26])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:27])[C:14]=2[CH:13]=1>CN(C=O)C>[Br-:10].[CH3:11][C:12]1[CH:25]=[CH:24][C:23]2[C:22](=[O:26])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:27])[C:14]=2[C:13]=1[N+:3]1[C:2]([Cl:1])=[C:6]([Cl:7])[N:5]([C:13]2[C:14]3[C:15](=[O:8])[C:16]4[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=4)[C:22](=[O:26])[C:23]=3[CH:24]=[CH:25][C:12]=2[CH3:11])[CH:4]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 1400184,5-DichloroimidazoleHCID 3444522-Bromomethyl-anthraquinone

생성물 1

HCID 86719692HCID 86719692, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

반응 조건

온도
80 °C

실험 절차

4,5-Dichloroimidazole (0.14 g, 1.0 mmol) and potassium hydroxide (0.06 g, 1.1 mmol) will be dissolved in the minimum volume of DMF in a high-pressure vessel. The solution will be heated at 80° C. for 30 min. The vessel will be removed from heat and 2-(bromomethyl)anthraquinone (1.20 g, 4.0 mmol) will be added. If not all solid dissolves, DMF will be added until all reactants are in solution. The vessel will be sealed and heated at 100° C. for 12 h. The volatile components will be removed under reduced pressure, and the remaining mixture washed with water to remove potassium bromide. The remaining solid will be collected and should be the product.

후처리

  1. customThe vessel will be removed
  2. temperaturefrom heat
  3. dissolutionIf not all solid dissolves
  4. customThe vessel will be sealed
  5. temperatureheated at 100° C. for 12 h
  6. customThe volatile components will be removed under reduced pressure
  7. washthe remaining mixture washed with water
  8. customto remove potassium bromide
  9. customThe remaining solid will be collected

출처 및 근거

ORD 기록
ord-6be74805d4c24c80a7e3c53051eaf821
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09278951B2

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