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Methanesulfonic Acid → Methanesulfonic acid 3-(4-chlorobenzyl)-1-methyl-2-oxo-cyclopentylmethyl ester

HRID 922737
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인쇄 미리보기

반응식

HRID 922737 반응식
COC([C:5]1([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH2:9][CH2:8][C:7]([CH2:11][O:12][S:13]([CH3:16])(=[O:15])=[O:14])([CH3:10])[C:6]1=[O:17])=O.CS(O)(=O)=O>O>[Cl:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][CH:5]2[CH2:9][CH2:8][C:7]([CH2:11][O:12][S:13]([CH3:16])(=[O:15])=[O:14])([CH3:10])[C:6]2=[O:17])=[CH:24][CH:23]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6395Methanesulfonic AcidHCID 867182541-(4-Chlorobenzyl)-3-methanesulfonyloxymethyl-3-methyl-2-oxo-cyclopentancarboxylic acid methyl ester

생성물 1

HCID 86718257Methanesulfonic acid 3-(4-chlorobenzyl)-1-methyl-2-oxo-cyclopentylmethyl ester

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
110 °C

실험 절차

To 1.26 g of Compound 3-1-1 obtained in Production Example 2, 0.255 ml of methanesulfonic acid and 88.3 mg of water were added, and the resulting mixture was stirred at 110° C. for 3.5 hours. After the reaction, water was added to the reaction solution thus obtained, and extraction with ethyl acetate was then carried out. The extract was washed with an aqueous solution of sodium hydrogen carbonate and saturated brine. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled away.

후처리

  1. additionwere added
  2. additionwas added to the reaction solution
  3. customthus obtained
  4. extractionextraction with ethyl acetate
  5. washThe extract was washed with an aqueous solution of sodium hydrogen carbonate and saturated brine
  6. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate
  7. distillationthe solvent was distilled away

출처 및 근거

ORD 기록
ord-4834d1e3a0d24272b1d1ff11bbc6667e
출처 데이터셋
uspto-grants-2016_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09278966B2

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