Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chlorosuccinimide → N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chlorosuccinimide | HCID 31398 | — |
| 반응물 | N-benzyl-4-(pyridin-2-yl)thiazol-2-amine | HCID 2902584 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine | HCID 58614641 | — |
반응 단계
A solution of N-benzyl-4-(pyridin-2-yl)thiazol-2-amine (60 mg, 0.23 mmol) in DMF (2 mL) was cooled to 0° C. and treated with N-chlorosuccinimide (33 mg, 0.25 mmol), and the reaction mixture was allowed to warm to room temperature. The solvent was evaporated, and the product was purified on reverse phase HPLC to produce N-benzyl-5-chloro-4-(pyridin-2-yl)thiazol-2-amine. MS (Q1) 302.2 (M)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09278961B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-633c0b3efab743debbe6075fbd2ec801 |
| 출처 메모 | uspto-grants-2016_03 |