Potassium Carbonate → 5-(1H-indazol-5-yl)-2-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

반응식

C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[NH:14][C:15]4[N:16]([N:20]=[C:21]([CH3:23])[N:22]=4)[C:17](=[O:19])[CH:18]=3)=[CH:10][CH:11]=2)[CH:6]=[N:5]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[NH:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]3[NH:14][C:15]4[N:16]([N:20]=[C:21]([CH3:23])[N:22]=4)[C:17](=[O:19])[CH:18]=3)=[CH:10][CH:11]=2)[CH:6]=[N:5]1

참가 물질

실험 절차

To a solution of 5-(1-acetyl-1H-indazol-5-yl)-2-methyl-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one (100 mg, crude) in methanol (3 ml) was added a solution of potassium carbonate (45 mg, 0.33 mmol) in water (1 ml), and the mixture was stirred overnight at room temperature. The resulting solution was concentrated under vacuum to give a residue, which was diluted with water (5 ml). The solids were collected by filtration and purified by Prep-HPLC to afford 5-(1H-indazol-5-yl)-2-methyl-[1,2,4]triazolo[1,5-α]pyrimidin-7(4H)-one as a white solid (28.7 mg, 7% 2 steps).