Nitric Acid → N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine
반응식
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][N:4]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[CH3:1][NH:2][C:3]1[C:8]([N+:18]([O-:20])=[O:19])=[CH:7][C:6]([C:9]([F:12])([F:10])[F:11])=[CH:5][N:4]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
To a mixture of N-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine (17.3 g) and sulfuric acid (100 ml), nitric acid (12.3 g) was added drop-wise, and stirred with heating at 80° C. for 2 hours. The mixture was cooled to room temperature, and then the reaction mixture was poured into water. The precipitate was collected by filtration, washed with water, and dried under reduced pressure to give 18.8 g of N-methyl-(3-nitro-5-trifluoromethyl-pyridin-2-yl)-amine.
후처리
- additionwas added drop-wise
- temperatureThe mixture was cooled to room temperature
- filtrationThe precipitate was collected by filtration
- washwashed with water
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-7ec808fd21c542bfbe744b8c65ea6091
- 출처 데이터셋
- uspto-grants-2016_03
- 특허 번호
- US09278983B2
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