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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 924044생성일: 2026년 10월 26일

(3S)-3-Pyrrolidinemethanol → (S)-5-bromo-6-(3-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide

https://huagongshe.com/reaction/924044

반응식

참여 물질

역할이름HCID투입량
반응물(3S)-3-PyrrolidinemethanolHCID 7446911—
반응물5-bromo-6-chloro-N-(4-((trifluoromethyl)thio)phenyl)nicotinamideHCID 86702605—
생성물(S)-5-bromo-6-(3-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-((trifluoromethyl)thio)phenyl)nicotinamideHCID 86702606—

반응 단계

The title compound was prepared in an analogous fashion to that described in Stage 186.1 using 5-bromo-6-chloro-N-(4-((trifluoromethyl)thio)phenyl)nicotinamide (Stage 185.2) and (S)-1-pyrrolidin-3-yl-methanol. HPLC (Condition 4) tR=6.17 min, UPLC-MS (Condition 3) tR=1.20 min, m/z=476.2/478.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09278981B2
출처 데이터셋uspto-grants-2016_03
ORD IDord-d0dc87c42d034d5a88d5bb773cb77b64
출처 메모uspto-grants-2016_03