5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 89906427, 화합물

반응식

[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[Cl:12][C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][C:19]=1[O:20][C:21]([F:24])([F:23])[F:22])[NH2:16]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:16][C:15]1[CH:17]=[CH:18][C:19]([O:20][C:21]([F:22])([F:23])[F:24])=[C:13]([Cl:12])[CH:14]=1)=[O:9]

참가 물질

반응물 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acid

HCID 27738433-Chloro-4-(trifluoromethoxy)aniline

생성물 1

HCID 89906427HCID 89906427, 화합물

실험 절차

The title compound was prepared in an analogous fashion to that described in Stage 185.2 using 5-bromo-6-chloro-nicotinic acid and 3-chloro-4-(trifluoromethoxy)aniline to afford an off-white crystalline solid. HPLC (Condition 4) tR=6.72 min, UPLC-MS (Condition 3) tR=1.34 min, m/z=429.0 [M−H]−.

후처리

customto afford an off-white crystalline solid

출처 및 근거

ORD 기록: ord-7e7adff301ed4ee1871c70e675d6bed8
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09278981B2

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