5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 89907270, 화합물

반응식

[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:25])([O:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1)[CH:14]([F:16])[F:15]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:22][C:21]1[CH:20]=[CH:19][C:18]([O:17][C:13]([F:12])([F:25])[CH:14]([F:15])[F:16])=[CH:24][CH:23]=1)=[O:9]

참가 물질

반응물 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acid

HCID 27766304-(1,1,2,2-tetrafluoroethoxy)aniline

생성물 1

HCID 89907270HCID 89907270, 화합물

실험 절차

The title compound was prepared in an analogous fashion to that described in Stage 169.2 using 5-bromo-6-chloro-nicotinic acid and 4-(1,1,2,2-tetrafluoroethoxy)aniline to afford a solid. UPLC-MS (Condition 3), tR=1.2 min, m/z=424.9 [M+H]+.

후처리

customto afford a solid

출처 및 근거

ORD 기록: ord-9f0f7ac28ec04da8ad5f555499c13bf1
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09278981B2

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