Water → HCID 66813488, 화합물

반응식

C(O[C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=O)C.[OH2:20]>>[CH3:19][C:14]1[C:13]2[C:18](=[CH:4][N:6]=[C:7]3[C:8]=2[C:9](=[O:20])[CH2:10][CH:11]=[CH:12]3)[CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 962Water

HCID 66813756HCID 66813756, 화합물

생성물 1

HCID 66813488HCID 66813488, 화합물수율 65%

반응 조건

온도: 170 °C

실험 절차

The above compound, N-ethoxycarbonyl-2-amino-2′methyl biphenyl (6.7 g, 26 mmol) was added to polyphosphoric acid (15 g) and heated to 170° C. overnight. After cooling, water was added and the white precipitate collected by vacuum filtration to give the 10-methyl-phenanthridinone (3.5 g, 65% yield) whose structure was consistent with CGMS and NMR.

후처리

temperatureAfter cooling
filtrationthe white precipitate collected by vacuum filtration

출처 및 근거

ORD 기록: ord-0ddeddb6d42e460fa48e0639bffbed7b
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09281483B2

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