1-Ethenyl-4-(trifluoromethyl)benzene → 4-Ethylbenzotrifluoride

HRID 924671

반응식

HRID 924671 반응식
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][CH:4]=1)=[CH2:2]>C1COCC1.[Pd]>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:7][CH:8]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 27827981-Ethenyl-4-(trifluoromethyl)benzene

생성물 1

HCID 53246974-Ethylbenzotrifluoride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 1-ethenyl-4-(trifluoromethyl)benzene (1.72 mL, 11.6 mmol) in THF (60 mL) was stirred in the presence of Pd/C (10%, 400 mg), under a hydrogen atmosphere (45 psi) for 7 h. The solid was filtered through celite (washed with DCM) and the filtrate was carefully concentrated, keeping the temperature of the bath below 20° C. at 200 mmHg. The concentrated solution thus obtained was used in the next step without further manipulation.

후처리

  1. filtrationThe solid was filtered through celite (washed with DCM)
  2. concentrationthe filtrate was carefully concentrated
  3. customthe temperature of the bath below 20° C.
  4. customThe concentrated solution thus obtained

출처 및 근거

ORD 기록
ord-be6e3d4980564493a300094b7485178b
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09283224B2

연결된 노트

불러오는 중…