Methyl 2-chloro-4-(hydroxymethyl)benzoate → Methyl 2-chloro-4-formylbenzoate

HRID 924996노트

반응식

HRID 924996 반응식
[Cl:1][C:2]1[CH:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>ClCCl.[O-2].[Mn+2]>[Cl:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

4

반응물 1

HCID 19780655Methyl 2-chloro-4-(hydroxymethyl)benzoate

생성물 1

HCID 57461225Methyl 2-chloro-4-formylbenzoate수율 62.2%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

반응 조건

온도
27 °C

실험 절차

A mixture of methyl 2-chloro-4-(hydroxymethyl)benzoate (350 mg, 1.7 mmol) in and manganese oxide (756 mg, 30.9 mmol) in dichloromethane (10 mL) was stirred at 27° C. for 6 hours. The mixture was filtered and evaporated in vacuo to give Intermediate 75 (210 mg, 61%).

후처리

  1. filtrationThe mixture was filtered
  2. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-f69f787f412247e291819f67d5635e5e
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09283229B2

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