Ammonium Hydroxide → 2,2,2-Trifluoroethane-1-sulfonamide

HRID 9253

반응식

HRID 9253 반응식
[C:1]([CH2:5][S:6](Cl)(=[O:8])=[O:7])([F:4])([F:3])[F:2].[NH4+:10].[OH-]>C(Cl)Cl.O>[C:1]([CH2:5][S:6]([NH2:10])(=[O:8])=[O:7])([F:4])([F:3])[F:2]

참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 742422,2,2-Trifluoroethanesulfonyl chloride

생성물 1

HCID 212655462,2,2-Trifluoroethane-1-sulfonamide

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

The CF3CH2SO2NH2 was prepared by cooling a solution of commercially available CF3CH2SO2Cl (0.6 ml, 1 eq) in CH2Cl2 to 0° C. NH4OH (0.75 ml, 14.8 N, 2 eq) was then added dropwise. The mixture was allowed to warm to room temperature overnight. The reaction was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried with Na2SO4 and concentrated. The sulfonamide was used without further purification.

후처리

  1. extractionextracted three times with CH2Cl2
  2. dry with materialThe combined organic layers were dried with Na2SO4
  3. concentrationconcentrated
  4. customThe sulfonamide was used without further purification

출처 및 근거

ORD 기록
ord-e82600096dac46b5b34ea78698e65332
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091230B2

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