Iodine → HCID 18541883, 화합물

HRID 925330노트

반응식

HRID 925330 반응식
[I:1]I.[F:3][C:4]1[CH:5]=[C:6]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[NH2:7]>C(O)C.S([O-])([O-])(=O)=O.[Ag+2]>[F:3][C:4]1[C:5]([I:1])=[C:6]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[NH2:7]

참가 물질

5

반응물 2

HCID 807IodineHCID 27249913,4,5-Trifluoroaniline

생성물 1

HCID 18541883HCID 18541883, 화합물수율 42%

시약·촉매·용매 2

HCID 178418844HCID 178418844, 화합물촉매HCID 702Ethanol용매

실험 절차

3,4,5-trifluoro-2-iodoaniline was prepared according to method D Step I with iodine (0.621 g; 2.45 mmol), silver sulphate (0.763 g; 2.45 mmol) and 3,4,5-trifluoroaniline (0.360 g; 2.45 mmol) in ethanol (5 mL). The crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to yield 0.279 g (42%) of 3,4,5-trifluoro-2-iodoaniline as a white solid.

후처리

  1. custom3,4,5-trifluoro-2-iodoaniline was prepared
  2. customThe crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane)

출처 및 근거

ORD 기록
ord-20ffaf9827c4465faa6c13e7162884cb
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284271B2

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