Triethylamine → HCID 67972953, 화합물

HRID 925332

반응식

HRID 925332 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH2:14].[O:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][N:22]=2)[CH2:17][CH2:16]1.C(N(CC)CC)C>ClCCl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:25](=[O:26])[C:24]1[CH:28]=[CH:29][C:21]([N:18]2[CH2:17][CH2:16][O:15][CH2:20][CH2:19]2)=[N:22][CH:23]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 27764616-Morpholinonicotinoyl ChlorideHCID 28274945-Chloro-1H-indole-3-ethylamine monohydrochloride

생성물 1

HCID 67972953HCID 67972953, 화합물수율 57%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide was obtained following Method C starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.042 g, 0.178 mmol), 6-morpholinonicotinoyl chloride (0.045 g; 0.178 mmol), and triethylamine (0.062 mL; 0.446 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel (eluent 1 to 10% methanol in dichloromethane) furnished 0.039 g (57%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide as a solid.

출처 및 근거

ORD 기록
ord-da783714262d4fa3aa320c7d4195c129
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284271B2

연결된 노트

불러오는 중…