Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| 반응물 | 5-Methyltryptamine hydrochloride | HCID 6917145 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide | HCID 1870500 | 73% |
반응 단계
N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide was obtained following Method C starting from 2-(5-methyl-1H-indol-3-yl)ethanamine hydrochloride (0.080 g, 0.372 mmol), biphenyl-4-carbonyl chloride (0.0864 g; 0.391 mmol), and triethylamine (0.131 mL; 0.930 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel eluting with 1 to 10% ethyl acetate in dichloromethane furnished 0.096 g (73%) of N-(2-(5-Methyl-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09284271B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-849fda2dc8914b0ba2feaf5548fb84f6 |
| 출처 메모 | uspto-grants-2016_03 |