Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1H-1,2,4-Triazole, 3,5-dimethyl- | HCID 139001 | — |
| 반응물 | 4,6-Dichloro-2-methylpyrimidine | HCID 234997 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine | HCID 62481745 | — |
반응 단계
A mixture of 4,6-dichloro-2-methylpyrimidine (505 mg, 3.1 mmol), 3,5-dimethyl-1H-1,2,4-triazole (300 mg, 3.1 mmol) and Cs2CO3 (1.54 g, 4.7 mmol) in THF (20 mL) was heated at reflux overnight. The mixture was filtered and the filtrate was concentrated to give 4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine that was used without further purification. MS: m/z=224.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09284302B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-df635fc5261f49109ebdfc55dd0943a2 |
| 출처 메모 | uspto-grants-2016_03 |