Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-methylaminobenzoate → 2-(Trimethylsilyl)ethyl 3-{[4-(methoxycarbonyl)phenyl](methyl)sulfamoyl}benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-methylaminobenzoate | HCID 140375 | — |
| 반응물 | 2-(Trimethylsilyl)ethyl 3-(chlorosulfonyl)benzoate | HCID 86676334 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 2-(Trimethylsilyl)ethyl 3-{[4-(methoxycarbonyl)phenyl](methyl)sulfamoyl}benzoate | HCID 71238276 | 73.3% |
반응 단계
A mixture of 1.50 g of 2-(trimethylsilyl)ethyl 3-(chlorosulfonyl)benzoate, 772 mg of methyl 4-(methylamino)benzoate, and 15 mL of pyridine was stirred at room temperature overnight, and then the reaction mixture was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 1.54 g of 2-(trimethylsilyl)ethyl 3-{[4-(methoxycarbonyl)phenyl](methyl)sulfamoyl}benzoate as a colorless oily substance. ESI+: 450
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09284295B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-4cc60d737d594629af33262fc4c45197 |
| 출처 메모 | uspto-grants-2016_03 |