Sodium Cyanide → HCID 66967418, 화합물

HRID 926239노트

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HRID 926239 반응식
[Cl:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH2:8][C:9]#[N:10])[CH:5]=[CH:6][CH:7]=1.BrCC1C=CC=C(Cl)C=1OC.[C-]#N.[Na+]>CCO.CCOCC>[Cl:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH2:8][CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 8929Sodium CyanideHCID 17989277(3-Chloro-2-methoxyphenyl)acetonitrileHCID 19390097HCID 19390097, 화합물

생성물 1

HCID 66967418HCID 66967418, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

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온도
100 °C

실험 절차

2-(3-chloro-2-methoxyphenyl)acetonitrile. A solution of 1-(bromomethyl)-3-chloro-2-methoxybenzene (30.8 g, 131 mmol) in EtOH (150 mL) at RT and under N2 was treated with an aq. solution of NaCN (12.8 g, 262 mmol in 50 mL H2O) and the mixture was heated to 100° C. for 3 h. The reaction was then cooled to RT and taken up in Et2O. The mixture was washed with H2O and brine, and the aq. phase was extracted again with Et2O. The combined org. layers dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography (SiO2, Hexane to Hexane/AcOEt 4:1) to afford the title compound (15.8 g) as brown oil. UPLC (2 min) rt 1.383.

후처리

  1. temperatureThe reaction was then cooled to RT
  2. washThe mixture was washed with H2O and brine
  3. extractionthe aq. phase was extracted again with Et2O
  4. dry with materiallayers dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe crude product was purified by flash chromatography (SiO2, Hexane to Hexane/AcOEt 4:1)

출처 및 근거

ORD 기록
ord-c416148c73b5435da5e14434576f3745
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284331B2

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