Isopropanol → HCID 71696589, 화합물

HRID 926399노트

반응식

HRID 926399 반응식
COC(C1CCCN1C(C1N2C(COCC2)=C(C(=O)N[C@@H](C2C=CC=CC=2)CC)C=1)=O)=O.[CH:33]([O:36][C:37]([CH:39]1[CH2:43]C[CH2:41][N:40]1[C:44]([C:46]1[N:54]2[C:49]([CH2:50][O:51][CH2:52][CH2:53]2)=[C:48]([C:55](=[O:66])[NH:56][C@@H:57]([C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)[CH2:58][CH3:59])[CH:47]=1)=[O:45])=[O:38])(C)[CH3:34].C(O)(C)C>C(O)C>[CH2:33]([O:36][C:37](=[O:38])[C@@H:39]([N:40]([CH3:41])[C:44]([C:46]1[N:54]2[C:49]([CH2:50][O:51][CH2:52][CH2:53]2)=[C:48]([C:55](=[O:66])[NH:56][C@@H:57]([C:60]2[CH:61]=[CH:62][CH:63]=[CH:64][CH:65]=2)[CH2:58][CH3:59])[CH:47]=1)=[O:45])[CH3:43])[CH3:34]

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 1265144481-[8-((R)-1-Phenyl-propylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]-pyrrolidine-2-carboxylic acid methyl esterHCID 1317350171-[8-((R)-1-Phenyl-propylcarbamoyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbonyl]-pyrrolidine-2-carboxylic acid isopropyl ester

생성물 1

HCID 71696589HCID 71696589, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The compound was obtained from comp. no. 16m as starting compound in analogy to the synthesis of comp. no. 16n. Isopropanol was replaced by ethanol to form the ester. LC/MS (method 4): Rt=1.24 min; m/z=454.27 (M+H+)

후처리

  1. customThe compound was obtained from comp
  2. customto the synthesis of comp

출처 및 근거

ORD 기록
ord-3425e88514154b2b9c11d9a78cb34839
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284333B2

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