Oxalyl chloride → 7-chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl adamantanecarboxylate

HRID 926440노트

반응식

HRID 926440 반응식
[C:1]12([C:11]([O:13][CH:14]3[CH:18]4[O:19][C:20](=[O:26])[CH:21]5[CH:22]([C:23](O)=[O:24])[CH:15]3[CH2:16][CH:17]45)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C(Cl)(=O)C([Cl:30])=O>C1(C)C=CC=CC=1>[C:1]12([C:11]([O:13][CH:14]3[CH:18]4[O:19][C:20](=[O:26])[CH:21]5[CH:22]([C:23]([Cl:30])=[O:24])[CH:15]3[CH2:16][CH:17]45)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 1181291646-adamantanecarbonyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-7-carboxylic acid

생성물 1

HCID 1181291597-chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl adamantanecarboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In 420 ml of toluene was suspended 60 g of the carboxylic acid (23) obtained in Synthesis Example 1-1-2. At 80° C., 25.3 g of oxalyl dichloride was added dropwise to the suspension, which was stirred for 4 hours. The toluene was distilled off in vacuum, obtaining the target compound. The resulting acid chloride was used in the subsequent reaction without further purification.

후처리

  1. customobtained in Synthesis Example 1-1-2
  2. distillationThe toluene was distilled off in vacuum
  3. customobtaining the target compound

출처 및 근거

ORD 기록
ord-85b39fa95c7a4c359bd7c0acf163ab2a
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09285678B2

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