(2,6-Dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol → (2,6-Dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanone

HRID 926477

반응식

HRID 926477 반응식
[CH3:1][C:2]1[C:7]([CH:8]([C:10]2[N:14]([CH3:15])[N:13]=[N:12][CH:11]=2)[OH:9])=[CH:6][CH:5]=[C:4]([CH3:16])[N:3]=1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[C:7]([C:8]([C:10]2[N:14]([CH3:15])[N:13]=[N:12][CH:11]=2)=[O:9])=[CH:6][CH:5]=[C:4]([CH3:16])[N:3]=1

참가 물질

4

반응물 1

HCID 86715641(2,6-Dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol

생성물 1

HCID 86715642(2,6-Dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanone

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 312751,4-Dioxane용매

반응 조건

온도
40 °C

실험 절차

A mixture containing (2,6-dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol (9.8 g, 44.9 mmol, Intermediate 19: step a) and manganese dioxide (18.8 g, 184 mmol) in dry dioxane (225 mL) was heated to 100° C. with stirring. After 1 hour, the mixture was cooled to 40° C. The cooled mixture was filtered through a 2 cm pad of Celite® and rinsed with tetrahydrofuran (100 mL). The filtrate was concentrated to provide the title compound as an off-white solid.

후처리

  1. filtrationThe cooled mixture was filtered through a 2 cm pad of Celite®
  2. washrinsed with tetrahydrofuran (100 mL)
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5302c08aae7846a3800691a42720828d
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284308B2

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