(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol → (1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

HRID 926501

반응식

HRID 926501 반응식
[CH3:1][N:2]1[C:6]([CH:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[OH:8])=[CH:5][N:4]=[CH:3]1>O1CCOCC1.[O-2].[O-2].[Mn+4]>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[O:8])=[CH:5][N:4]=[CH:3]1

참가 물질

4

반응물 1

HCID 86715604(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol

생성물 1

HCID 86715605(1-Methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanone

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 312751,4-Dioxane용매

실험 절차

A heterogenous mixture of (1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol (1.41 g, 7.45 mmol, Intermediate 33: step a) and manganese dioxide (3.24 g, 37.27 mmol) in 1,4-dioxane (52 mL) was stirred at 100° C. for 2 hours. The reaction mixture was then cooled to room temperature, filtered through Celite®, washed with DCM, and concentrated to provide the title compound as an off-white solid.

후처리

  1. filtrationfiltered through Celite®
  2. washwashed with DCM
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b311ad1dec01437892ff3059d79c7e1d
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284308B2

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