HCID 74220613, 화합물 → (4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-4-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol

HRID 926612

반응식

HRID 926612 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](C(C3C(C)=NC(C)=CC=3)O)[CH:10]=2)[N:5]=[C:4]([O:22][CH3:23])[C:3]=1[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=1.N1(C2C=CC(CC3C(Cl)=NC4C(C=3Cl)=CC(Br)=CC=4C)=CC=2)C=C[CH:37]=N1.[CH3:61][N:62]1[C:66]([C:67]([C:69]2[CH:74]=[CH:73][N:72]=[C:71]([C:75](F)(F)F)[CH:70]=2)=[O:68])=[CH:65][N:64]=[N:63]1.S1C(CC2C(OC)=NC3C(C=2Cl)=CC(C(C2N(C)C=NC=2)(C2C=NC(C(F)(F)F)=CC=2)O)=CC=3)=CC2C=CC=CC1=2>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:67]([C:69]3[CH:70]=[C:71]([CH3:75])[N:72]=[C:73]([CH3:37])[CH:74]=3)([C:66]3[N:62]([CH3:61])[N:63]=[N:64][CH:65]=3)[OH:68])[CH:10]=2)[N:5]=[C:4]([O:22][CH3:23])[C:3]=1[CH2:24][C:25]1[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=1

참가 물질

5

반응물 4

HCID 74220613HCID 74220613, 화합물HCID 867155983-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinolineHCID 86715629(4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanol2회HCID 118006204(1-methyl-1H-1,2,3-triazol-5-yl)(2-(trifluoromethyl)pyridin-4-yl)methanone2회

생성물 1

HCID 118006342(4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-4-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol

실험 절차

The title compound was prepared analogously to the method described in Example 78 using 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline (Intermediate 12: step d) in place of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinoline (Intermediate 57) and (1-methyl-1H-1,2,3-triazol-5-yl)(2-(trifluoromethyl)pyridin-4-yl)methanone (Intermediate 29: step b) in place of 1-(4-(6-(trifluoromethyl)nicotinoyl)piperidin-1-yl)ethanone (Intermediate 56: step d). MS m/e 568.2 (M+H)+.

출처 및 근거

ORD 기록
ord-373006d99a2846dea481aad80cd844e2
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09284308B2

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