Ethyl 3-aminocyclohexanecarboxylate → (3-Aminocyclohexyl)methanol

HRID 926724

반응식

HRID 926724 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14](OCC)=[O:15])[CH2:9]1>C1COCC1>[NH2:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][OH:15])[CH2:9]1

참가 물질

4

반응물 2

HCID 418531Ethyl 3-aminocyclohexanecarboxylateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 55290182(3-Aminocyclohexyl)methanol수율 82.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
27.5 °C

실험 절차

LAH (107 mg, 2.8 mmol) was added portionwise to a solution of ethyl 3-aminocyclohexanecarboxylate (320 mg, 1.87 mmol) in THF (5 mL) at 0° C. and continued stirring at 25-30° C. for 15 h. The reaction mixture was quenched with aqueous saturated sodium sulphate solution, filtered the solid precipitate, washed the solid with THF; the filtrate collected was concentrated under reduced pressure to afford 200 mg of the title compound.

후처리

  1. customThe reaction mixture was quenched with aqueous saturated sodium sulphate solution
  2. filtrationfiltered the solid precipitate
  3. washwashed the solid with THF
  4. customthe filtrate collected
  5. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-36b5b373046f4b008e295452a1e07d8d
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09289419B2

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