Ammonium Chloride → HCID 178525126, 화합물

HRID 926729

반응식

HRID 926729 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].[NH4+].[Cl-].[C:7]([CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:11][CH2:10]1)#[N:8]>CN(C=O)C>[NH:1]1[C:7]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][CH2:18][C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[O:16])[CH2:11][CH2:10]2)=[N:8][N:3]=[N:2]1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 22028286Benzyl 4-cyanopiperidine-1-carboxylate

생성물 1

HCID 178525126HCID 178525126, 화합물수율 19.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

NaN3(1.7 g, 26.14 mmol) and NH4Cl (1.75 g, 32.7 mmol) were added to the solution of benzyl 4-cyanopiperidine-1-carboxylate (1.6 g, 26.14 mmol) in DMF (16 mL) and stirring was continued at 90° C. for 24 h. The reaction mixture was quenched with 10% aqueous citric acid solution, extracted with EtOAc, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 1.45 g of the title compound.

후처리

  1. customThe reaction mixture was quenched with 10% aqueous citric acid solution
  2. extractionextracted with EtOAc
  3. dry with materialdried over anhydrous sodium sulphate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-99f3c516f0ec4d8bb63468ee6654a898
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09289419B2

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