Potassium Hydroxide → Amantadine

반응식

Cl.[C:2]12([NH2:12])[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2.[OH-].[K+]>>[C:2]12([NH2:12])[CH2:9][CH:8]3[CH2:7][CH:6]([CH2:5][CH:4]([CH2:10]3)[CH2:3]1)[CH2:11]2

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 64150Amantadine Hydrochloride

생성물 1

HCID 2130Amantadine

실험 절차

An aqueous solution of 1-adamantylamine hydrochloride (Alfa-Aesar, 99%) was treated with potassium hydroxide and extracted with toluene, dried over Na2SO4, filtered and stripped down by rotary evaporation to give 30.3 g 1-adamantylamine (200 mmol). The procedure for compound 1, above, was followed except the reaction was heated at 45° C. overnight yielding 26.23 g white solids (62.8 mmol, 63% yield). When performing the activated carbon treatment 2:1 water/absolute ethanol was used to dissolve the residue.

후처리

extractionextracted with toluene
dry with materialdried over Na2SO4
filtrationfiltered
customstripped down by rotary evaporation

출처 및 근거

ORD 기록: ord-2a96ff9932fe44e98afecd7913bfb30a
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09289757B2

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