1,1-Dimethoxyethyl(dimethyl)amine → 2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide
반응식
[Br:1][C:2]1[CH:3](O)[CH2:4][CH2:5][CH:6]=1.C[O:9][C:10](OC)([N:12]([CH3:14])[CH3:13])[CH3:11]>C1(C)C=CC=C(C)C=1>[Br:1][C:2]1[CH:3]([CH2:11][C:10]([N:12]([CH3:14])[CH3:13])=[O:9])[CH2:4][CH2:5][CH:6]=1참가 물질
4
실험 절차
2-Bromo-cyclopent-2-enol (Intermediate D3) (2.18 g, 13.4 mmol) and N,N-dimethylacetamide dimethyl acetal (3.5 mL, 21.5 mmol) in m-xylene (˜20 mL) were heated to 140° C. for 14 h. The mixture was freed of solvent and the residue was purified on a column of silica gel with 30% to 50% EtOAc:hexanes to give 2-(2-bromo-cyclopent-2-enyl)-N,N-dimethyl-acetamide (Intermediate FOUR1) 1.95 g (63%) as a brown oil.
후처리
- customthe residue was purified on a column of silica gel with 30% to 50% EtOAc
출처 및 근거
- ORD 기록
- ord-b08eddab25a944edabedd2575e1e1f78
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07091232B2
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