Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-5-iodotoluene → 3,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-5-iodotoluene | HCID 521178 | — |
| 반응물 | 3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine | HCID 71269910 | — |
| 반응물 | 3,4-Bis(benzyloxy)-6-ethynylpyridazine | HCID 86677025 | — |
| 생성물 | 3,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine | HCID 71270369 | 67% |
반응 단계
Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-fluoro-4-iodo-2-methylbenzene in 67% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09290456B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-94a8618523ab4b7a8ec572cad712a576 |
| 출처 메모 | uspto-grants-2016_03 |