Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-3-fluorobenzotrifluoride → 3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-3-fluorobenzotrifluoride | HCID 142414 | — |
| 반응물 | 3,4-Bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazine | HCID 71269897 | — |
| 반응물 | 3,4-Bis(benzyloxy)-6-ethynylpyridazine | HCID 86677025 | — |
| 생성물 | 3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazine | HCID 71270511 | 16% |
반응 단계
Prepared as described for 3,4-bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazine (Intermediate 74) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-bromo-2-fluoro-4-(trifluoromethyl)benzene in 16% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09290456B2 |
| 출처 데이터셋 | uspto-grants-2016_03 |
| ORD ID | ord-47ade3eda15144e2a56378d05b86e767 |
| 출처 메모 | uspto-grants-2016_03 |