HCID 71269819, 화합물 → HCID 178518785, 화합물

HRID 927152노트

반응식

HRID 927152 반응식
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]2([C:42]3[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=3)[CH2:41][CH2:40]2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>C(OCC)(=O)C>[F:48][C:45]1[CH:44]=[CH:43][C:42]([C:39]2([C:28]3[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=3)[CH2:41][CH2:40]2)=[CH:47][CH:46]=1

참가 물질

4

반응물 2

HCID 71269819HCID 71269819, 화합물2회HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

생성물 1

HCID 178518785HCID 178518785, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[1-(4-fluorophenyl)cyclopropyl]pyridazine (Intermediate 42) except that the solvent used for the hydrogenation was ethyl acetate and the product was recrystallised from a mixture of ethyl acetate and MTBE.

후처리

  1. customthe product was recrystallised from a mixture of ethyl acetate and MTBE

출처 및 근거

ORD 기록
ord-0c1f4adf06874259be82761078af931c
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290456B2

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