참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | 2-Amino-5-nitrobenzoic acid | HCID 12032 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 6-Nitro-2,4(1H,3H)-quinazolinedione | HCID 816982 | 73.2% |
반응 단계
A mixture of 2-amino-5-nitrobenzoic acid (0.588 g, 3.23 mmol) and urea (1.164 g, 19.38 mmol) was heated at 200° C. under N2 for 1 h. The mixture was cooled to room temperature and 4 M NaOH was added until pH=14. It was acidified to pH=5.0 via addition of AcOH. The mixture was filtered and the yellow solid was dried to give the title compound (0.49 g, 72.8%) as a yellow solid. MS: m/z 208.1 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09290460B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_03 |
|---|
| ORD ID | ord-769710638e4c43b2b24dd08fbb7b2248 |
|---|
| 출처 메모 | uspto-grants-2016_03 |
|---|
