6-Cyclohexenyl-pyridine-2-carboxylic acid → 6-Cyclohexyl-pyridine-2-carboxylic acid

HRID 927343

반응식

HRID 927343 반응식
[C:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>C(O)C.[Pd]>[CH:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 1

HCID 710872336-Cyclohexenyl-pyridine-2-carboxylic acid

생성물 1

HCID 681621566-Cyclohexyl-pyridine-2-carboxylic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 6-cyclohexenyl-pyridine-2-carboxylic acid (0.8 g, 3.94 mmol) in ethanol (50 mL) was added 10% palladium on carbon (20%, 0.16 g) under an atmosphere of nitrogen. The suspension was degassed under vacuum and exchanged with hydrogen several times. The mixture was stirred under hydrogen balloon at ambient temperature overnight. The reaction mixture was filtered through a pad of celite, the pad was washed with ethanol and the combined filtrates were concentrated to dryness. The crude title compound (0.62 g, green oil) was used for the next reaction step without further purification; MS (EI): m/e 206.2 [M+H]+

후처리

  1. customThe suspension was degassed under vacuum
  2. filtrationThe reaction mixture was filtered through a pad of celite
  3. washthe pad was washed with ethanol
  4. concentrationthe combined filtrates were concentrated to dryness
  5. customThe crude title compound (0.62 g, green oil) was used for the next reaction step without further purification

출처 및 근거

ORD 기록
ord-c5b7db4d7b3649f38cba0c072bdf07f4
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

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