2-Amino-2-ethylbutan-1-ol → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-hydroxymethyl-propyl)-amide

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:17][C:18]([CH2:23][CH3:24])([CH2:21][CH3:22])[CH2:19][OH:20]>>[CH2:21]([C:18]([NH:17][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([CH2:19][OH:20])[CH2:23][CH3:24])[CH3:22]

참가 물질

반응물 2

HCID 143256072-Amino-2-ethylbutan-1-ol

HCID 247301356-(3-Chlorophenyl)picolinic acid

생성물 1

HCID 710936436-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-hydroxymethyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and 2-amino-2-ethyl-1-butanol (CAN 19792-52-0) as starting materials, MS (LC/MS): 333.1 (M+H).

출처 및 근거

ORD 기록: ord-fe3b7b1d0a1e465aa1cfd979ecbd5f31
출처 데이터셋: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09290451B2

반응 노트

불러오는 중…