2-(1,3-Thiazol-2-yl)propan-2-amine → 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

HRID 927447

반응식

HRID 927447 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]([OH:17])=O)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1.[CH3:18][C:19]([CH3:26])([C:21]1[S:22][CH:23]=[CH:24][N:25]=1)[NH2:20]>>[CH3:18][C:19]([NH:20][C:15]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[N:6]=1)=[O:17])([C:21]1[S:22][CH:23]=[CH:24][N:25]=1)[CH3:26]

참가 물질

3

반응물 2

HCID 282862032-(1,3-Thiazol-2-yl)propan-2-amineHCID 710876195-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid

생성물 1

HCID 711055695-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (LC/MS): 392.0 [M+H]+.

출처 및 근거

ORD 기록
ord-2c5969ee0ab74496af9934a730516e88
출처 데이터셋
uspto-grants-2016_03
특허 번호
US09290451B2

연결된 노트

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